Keywords
How to Cite
Abstract
Ménétrier’s disease is a rare human condition that causes diffuse hypertrophy of the gastric rugal folds. A similar condition in dogs has been reported as Ménétrier-like disease (MLD). To date, only two feline cases have been reported, and treatment was either unsuccessful or not documented. A 3-year-old female spayed Devon Rex cat was presented with acute nausea, retching, and vomiting. Within two months, multiple tests were performed to reach the diagnosis. Macroscopically, during gastroduodenoscopy, cerebriform hypertrophic gastric mucosal folds were observed in the gastric fundus, cardia, and greater curvature of the stomach. Superficial biopsy sampling of the gastric mucosa showed mild mucosal oedema and low numbers of Helicobacter spp. Considering the course of the disease, persistent gastrointestinal symptoms, and quality of life, a partial gastrectomy was performed. Histology of full-thickness biopsies confirmed hyperplastic fibrosing gastropathy with multifocal cystic dilated gastric glands resembling Ménétrier-like disease in dogs. At the time of the 3-month follow-up, the cat was asymptomatic, and the gastroduodenoscopy was unremarkable. This case report presents clinical findings, challenging diagnostics, and a novel treatment option in a cat with hyperplastic fibrosing gastropathy. To the authors‘knowledge, this is the first reported successful surgical management of MLD in a cat.
References
Badov, D., Lambert, J. R., Finlay, M., & Balazs, N. D. (1998). Helicobacter pylori as a pathogenic factor in Ménétrier’s disease. The American Journal of Gastroenterology, 93(10), 1976-1979. http://doi.org/10.1111/j.1572-0241.1998.00347.x. PMid:9772069.
Barker, E. N., Holdsworth, A. S., Hibbert, A., Brown, P. J., & Hayward, N. J. (2019). Hyperplastic and fibrosing gastropathy resembling Ménétrier disease in a cat. Journal of Feline Medicine and Surgery Open Reports, 5(2), 2055116919861248. http://doi.org/10.1177/2055116919861248. PMid:31308958.
Bayerdörffer, E., Ritter, M. M., Hatz, R., Brooks, W., Ruckdeschel, G., & Stolte, M. (1994). Healing of protein losing hypertrophic gastropathy by eradication of Helicobacter pylori--is Helicobacter pylori a pathogenic factor in Ménétrier’s disease? Gut, 35(5), 701-704. http://doi.org/10.1136/gut.35.5.701. PMid:8200570.
Coffey, R. J., Washington, M. K., Corless, C. L., & Heinrich, M. C. (2007). Menetrier disease and gastrointestinal stromal tumors: Hyperproliferative disorders of the stomach. The Journal of Clinical Investigation, 117(1), 70-80. http://doi.org/10.1172/JCI30491. PMid:17200708.
Dennis, R., Herrtage, M. E., Jefferies, A. R., Matic, S. E., & White, R. A. S. (1987). A case of hyperplastic gastropathy in a cat. The Journal of Small Animal Practice, 28(6), 491-504. http://doi.org/10.1111/j.1748-5827.1987.tb01442.x.
Emerson, J. A., Adkesson, M. J., Colegrove, K. M., Burdick, S. K., & Langan, J. N. (2014). Ménétrier’s disease-like hypertrophic gastritis in two red-capped mangabeys (Cercocebus torquatus). The Veterinary Quarterly, 34(1), 29-36. http://doi.org/10.1080/01652176.2014.894263. PMid:24625015.
Friedman, J., Platnick, J., Farruggia, S., Khilko, N., Mody, K., & Tyshkov, M. (2009). Ménétrier disease. Radiographics, 29(1), 297-301. http://doi.org/10.1148/rg.291075216. PMid:19168850.
Jang, H., Lee, S. W., Jang, M., Yun, S., Kwon, Y. S., Park, J. K., & Lee, K. (2021). Hypertrophic pyloric gastropathy with Helicobacter spp. in a dog. Korean Journal of Veterinary Research, 61(1), e3. http://doi.org/10.14405/kjvr.2021.61.e3.
Kelly, D. G., Miller, L. J., Malagelada, J. R., Huizenga, K. A., & Markowitz, H. (1982). Giant hypertrophic gastropathy (Menetrier’s disease): Pharmacologic effects on protein leakage and mucosal ultrastructure. Gastroenterology, 83(3), 581-589. http://doi.org/10.1016/S0016-5085(82)80193-5. PMid:6124476.
Lagerstedt, E., Spillmann, T., Airas, N., Solano-Gallego, L., & Kilpinen, S. (2021). Ménétrier-like disease in a Pointer with concurrent granulomatous gastritis, helicobacteriosis and leishmaniosis: A case report. BMC Veterinary Research, 17(1), 98. http://doi.org/10.1186/s12917-021-02802-3. PMid:33653341.
Lecoindre, P., Bystricka, M., Chevallier, M., & Peyron, C. (2012). Gastric carcinoma associated with Menetrier’s‐like disease in a West Highland white terrier. The Journal of Small Animal Practice, 53(12), 714-718. http://doi.org/10.1111/j.1748-5827.2012.01291.x. PMid:23034016.
Menetrier, P. (1888). Des polyadenomes gastriques et deleurs rapports avec le cancer de l’estomac. Arch Physiol Norm Path, 1, 32-55.
Munday, J. S., Aberdein, D., Cullen, G. D., & French, A. F. (2012). Ménétrier disease and gastric adenocarcinoma in 3 Cairn terrier littermates. Veterinary Pathology, 49(6), 1028-1031. http://doi.org/10.1177/0300985812439076. PMid:22411550.
Rallis, T. S., Patsikas, M. N., Mylonakis, M. E., Day, M. J., Petanides, T. A., Papazoglou, L. G., & Koutinas, A. F. (2007). Giant hypertrophic gastritis (Ménétrier’s-like disease) in an Old English sheepdog. Journal of the American Animal Hospital Association, 43(2), 122-127. http://doi.org/10.5326/0430122. PMid:17339290.
Romanucci, M., Crisi, P. E., Giordano, M. V., Di Tommaso, M., Simeoni, F., & Della Salda, L. (2021). Hypertrophic gastropathy associated with gastric sarcoma in a dog. Journal of Veterinary Diagnostic Investigation, 33(1), 112-115. http://doi.org/10.1177/1040638720966972. PMid:33090082.
Sarandy, T. B., Lopes, C. E. B., Del Piero, F., & Ecco, R. (2021). Metastatic gastric adenocarcinoma associated with hypertrophic gastropathy resembling Ménétrier’s disease in an adult Labrador Retriever dog. Brazilian Journal of Veterinary Pathology, 14(2), 123-128. http://doi.org/10.24070/bjvp.1983-0246.v14i2p123-128.
Scott Junior, H. W., Shull, H. J., Law IV, D. H., Burko, H. E. N. R. Y., & Page, D. L. (1975). Surgical management of Menetrier’s disease with protein-losing gastropathy. Annals of Surgery, 181(5), 765-777. http://doi.org/10.1097/00000658-197505000-00036. PMid:1130890.
Taillieu, E., Chiers, K., Amorim, I., Gärtner, F., Maes, D., Van Steenkiste, C., & Haesebrouck, F. (2022). Gastric Helicobacter species associated with dogs, cats and pigs: Significance for public and animal health. Veterinary Research, 53(1), 42. http://doi.org/10.1186/s13567-022-01059-4. PMid:35692057.
Toubia, N., & Schubert, M. L. (2008). Menetrier’s disease. Current Treatment Options in Gastroenterology, 11(2), 103-108. http://doi.org/10.1007/s11938-008-0022-x. PMid:18321437.
van der Gaag, I. (1984). Hypertrophic gastritis in 21 dogs. Zentralbl Veterinarmed A, 31(1-10), 161-173.
van der Gaag, I., Happé, R. P., & Wolvekamp, W. T. C. (1976). A boxer dog with chronic hypertrophic gastritis resembling Menetrier’s disease in man. Veterinary Pathology, 13(3), 172-185. http://doi.org/10.1177/030098587601300302. PMid:936424.
Vaughn, D. P., Syrcle, J., & Cooley, J. (2014). Canine giant hypertrophic gastritis treated successfully with partialgastrectomy. Journal of the American Animal Hospital Association, 50(1), 62-66. http://doi.org/10.5326/JAAHA-MS-5952. PMid:24216500.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Evelina Burbaitė, Vytautas Stankus, Cynthia de Vries, Brigita Bandzevičiūtė, Vytautas Sabūnas