Keywords
How to Cite
Abstract
Gastrointestinal helminthiases in domestic cats aret a significant concern for both animal and human health due to the zoonotic potential of parasites such as Ancylostoma spp., Toxocara spp. and Dipylidium caninum. The increasingly close coexistence between humans and cats in urban environments increases the need for effective and practical strategies for parasite control. We evaluated the efficacy of an antiparasitic formulation based on fipronil, moxidectin and praziquantel (Banni3®) for topical application. A total of 38 cats infected by the helminths of interest were evaluated and the helminths were found to belong to more than one genus. Coproparasitological evaluations were performed on days D-7 and D-2 (pre-treatment) and D+7 and D+14 (post-treatment) using the modified McMaster technique to count eggs per gram of feces (EPG). In the case of D. caninum, proglottids and ovigerous capsules were also analyzed. Of the animals tested, 38 were positive for Ancylostoma spp., 20 for Toxocara spp. and 22 for D. caninum. Six animals had infections by helminths of a single genus, 22 by two and 10 by all three genera. After treatment, the results indicated efficacy of 97.4% (D+7) and 99% (D+14) for Ancylostoma spp., 96.12% (D+7) and 97.84% (D+14) for Toxocara spp., and 100% (D+7 and D+14) for D. caninum. The topical formulation Banni3® (fipronil, moxidectin, and praziquantel) demonstrated high efficacy in controlling Ancylostoma spp., Toxocara spp., and D. caninum in naturally infected cats. The results confirm its potential as a practical and effective alternative for the control of zoonotic helminths.
References
Arisov, M. V., Indyuhova, E. N., & Arisova, G. B. (2019). Pharmacokinetics of combination antiparasitic drug preparation for dogs and cats in the form of spot-on solution. Journal of Advanced Veterinary and Animal Research, 6(1), 25-32. http://doi.org/10.5455/javar.2019.f308. PMid:31453167.
Ballatore Holland Lins, S., Cavalheiros Dorval, M. E., Jardim Cury Pontes, E. R., Antunes Nogueira, A. P., Ferreira, E. C., & Cepa Matos, M. F. (2021). Parasites of Zoonotic Interest Detectedin Felis catus domesticus in Midwestern Brazil. Ensaios e Ciência: Ciências Biológicas, Agrárias e da Saúde, 25(1), 29-33. http://doi.org/10.17921/1415-6938.2021v25n1p29-33.
Beugnet, F., Taweethavonsawat, P., Traversa, D., Fourie, J., McCall, J., Tielemans, E., & Geurden, T. (2022).
World Association for the Advancement of Veterinary Parasitology (WAAVP): second edition of guidelines for evaluating the efficacy of anthelmintics for dogs and cats. Veterinary Parasitology, 312, 109815. http://doi.org/10.1016/j.vetpar.2022.109815.
Campos, D. R., Marré, E. O., Cruz, B. C., Cruz, G. A. M., Michels, M. G., Gatto, I. R. H., de Almeida, F. N., Rosa, D. Q., Correia, T. R., & Scott, F. B. (2025). Efficacy of a topical formulation combining fipronil, moxidectin, and praziquantel (Banni3) in controlling flea infestation in cats. Frontiers in Veterinary Science, 12, 1551961. http://doi.org/10.3389/fvets.2025.1551961. PMid:40046424.
Cutolo, A. A., Jardina, D. T. G., De Vito, G. G., Grisi do Nascimento, C., Heidmann, M. J., Ferreira Nantes, J. D., Bassetto, K. V., Chagas, I. C., Pereira Junior, E. F., de Castro, B. G., & Tielemans, E. (2022). Efficacy of two endectoparasiticide products combining fipronil and (S)-methoprene or esafoxolaner with eprinomectin and praziquantel against fleas and intestinal helminths in cats naturally infested in Brazil. Parasite (Paris, France), 29, 12. http://doi.org/10.1051/parasite/2022012. PMid:35238771.
European Medicines Agency. (2000). VICH GL9 Good clinical practices - Scientific guideline. https://www.ema.europa.eu/en/vich-gl9-good-clinical-practices-scientific-guideline
European Scientific Counsel Companion Animal Parasites. (2021). GL1: Worm control in dogs and cats. Esccap.org. https://www.esccap.org/guidelines/gl1/
Ferreira, L. E. B., Ribeiro, L. A., & Pinto, J. M. S. (2020). Ocorrência de parasitos gastrointestinais de gatos domésticos (Felis catus domesticus) em amostras fecais recebidas no hospital veterinário da Universidade Estadual de Santa Cruz no período de 2018-2019. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, 23(2cont), e2305. http://doi.org/10.25110/arqvet.v23i2cont.2020.7702.
Gordon,H. Mcl. and Whitlock,H. V. (1939) ‘’ A New Technique for Counting Nematode Eggs in Sheep Faeces’’, English, Journal article, 12, Journal of the Council for Scientific and Industrial Research, Australia, (50–52).
López-Osorio, S., Penagos-Tabares, F., & Chaparro-Gutiérrez, J. J. (2020). Prevalence of Toxocara spp. in dogs and cats in South America (excluding Brazil). In D. D. Bowman (Ed.), Advances in Parasitology (pp. 743-778). Elsevier. http://doi.org/10.1016/bs.apar.2020.01.029.
Rinaldi, L., Krücken, J., Martinez-Valladares, M., Pepe, P., Maurelli, M. P., de Queiroz, C., Castilla Gómez de Agüero, V., Wang, T., Cringoli, G., Charlier, J., Gilleard, J. S., & von Samson-Himmelstjerna, G. (2022). Advances in diagnosis of gastrointestinal nematodes in livestock and companion animals. In D. D. Bowman (Ed.), Advances in Parasitology (pp. 85-176). Elsevier. http://doi.org/10.1016/bs.apar.2022.07.002.
Taylor, S., Caney, S., Bessant, C., & Gunn-Moore, D. (2022). Online survey of owners’ experiences of medicating their cats at home. Journal of Feline Medicine and Surgery, 24(12), 1283-1293. http://doi.org/10.1177/1098612X221083752. PMid:35343808.
Zajíčková, M., Nguyen, L. T., Skálová, L., Raisová Stuchlíková, L., & Matoušková, P. (2020). Anthelmintics in the future: Current trends in the discovery and development of new drugs against gastrointestinal nematodes. Drug Discovery Today, 25(2), 430-437. http://doi.org/10.1016/j.drudis.2019.12.007. PMid:31883953.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Diefrey Ribeiro Campos, Anna Carolina Teixeira de Jesus, Ronald da Silva Souza Junior, Breno Cayeiro Cruz, Gessica Ariane de Melo Cruz, Milenni Garcia Michels, Igor Renan Honorato Gatto, Ferdinando Nielsen Almeida, Thais Ribeiro Correia, Fabio Barbour Scott