Successful deslorelin implant treatment in a neutered female Pomeranian dog with Alopecia X
PDF
XML

Keywords

GnRH analog, suprelorin, hair cycle arrest, noninflammatory alopecia, sex steroids.

How to Cite

Coimbra, P. A. B., & Vieira, A. B. (2025). Successful deslorelin implant treatment in a neutered female Pomeranian dog with Alopecia X. Brazilian Journal of Veterinary Medicine, 47(1), e001325. https://doi.org/10.29374/2527-2179.bjvm001325

Abstract

The Pomeranian dog is recognized as one of the predisposed breeds for alopecia X, a noninflammatory hair cycle arrest disorder. Although it is considered a cosmetic issue unrelated to systemic illness, having a pet with alopecia can be distressing for owners. Sex steroid imbalance seems to influence the development of alopecia X, but the exact pathogenesis is still unknown. Although some treatment alternatives are currently available for alopecia X, results can vary, as well as costs, risks, and owner adherence. GnRH analogs have been used extensively in the modulation of sex hormone synthesis in humans. Previous studies support the use of the GnRH analog in treating male dogs with alopecia X, but current literature discourages its use in females. We aim to report the first scientific description of a neutered female dog with alopecia X successfully treated with a 4.7 mg deslorelin acetate implant after failing to respond to melatonin. Profuse hair regrowth took 9 months to occur after the first implant, but the treatment was considered uncomplicated, cost-effective, and safe.

https://doi.org/10.29374/2527-2179.bjvm001325
PDF
XML

References

Albanese, F., Malerba, E., Abramo, F., Miragliotta, V., & Fracassi, F. (2014). Deslorelin for the treatment of hair cycle arrest in intact male dogs. Veterinary Dermatology, 25(6), 519-522, e87-8. http://doi.org/10.1111/vde.12148. PMid:25066263.

Amado Martins, F., Almeida da Silva, G., Ligeiro de Oliveira, A. P., Gutierrez Duran, C. C., Constantin Baltatu, O., Labat Marcos, R., Ratto Tempestini Horliana, A. C., Regina Zamuner, S., & Antonio Silva Junior, J. (2024). Comparison between melatonin versus melatonin and photobiomodulation versus photobiomodulation in the treatment of Alopecia X in German Spitz dogs: Clinical, randomized, double-blind, parallel, non-inferiority protocol. PLoS One, 19(6), e0304605. http://doi.org/10.1371/journal.pone.0304605. PMid:38861499.

Amaral, J., Briantais, P., Fontaine, C., & Rigaut, D. (2023). Efficacy and safety of 4.7 mg deslorelin acetate implants as a neutering option in male cats: a large-scale multicentre randomised controlled study. Animals (Basel), 13(3), 379. http://doi.org/10.3390/ani13030379. PMid:36766268.

Bamberg, E., Aichinger, A., & Mitteregger, G. (2004). In vitro metabolism of dehydroepiandrosterone and testosterone by canine hair follicle cells. Veterinary Dermatology, 15(1), 19-24. http://doi.org/10.1111/j.1365- 3164.2004.00366.x. PMid:14989701.

Bamberg, E., Aichinger, A., & Wünsch, G. (2005). In vitro metabolism of progesterone by canine hair follicle cells. Veterinary Dermatology, 16(3), 153-155. http://doi.org/10.1111/j.1365-3164.2005.00450.x. PMid:15960627.

Bratka‐Robia, C. B., Egerbacher, M., Helmreich, M., Mitteregger, G., Benesch, M., & Bamberg, E. (2002). Immunohistochemical localization of androgen and oestrogen receptors in canine hair follicles. Veterinary Dermatology, 13(2), 113-118. http://doi.org/10.1046/j.1365-3164.2002.00287.x. PMid:11972894.

Casteel, C. O., & Singh, G. (2020). Physiology, gonadotropin-releasing hormone. NIH. [[Q3: Q3]]

Cerundolo, R., & Warren, S. (2013). The use of deslorelin to promote hair regrowth in dogs with alopecia X. Veterinary Dermatology, 24, 377-397.

Cerundolo, R., Lloyd, D. H., Persechino, A., Evans, H., & Cauvin, A. (2004). Treatment of canine Alopecia X with trilostane. Veterinary Dermatology, 15(5), 285-293. http://doi.org/10.1111/j.1365-3164.2004.00403.x. PMid:15500480.

Cerundolo, R., Lloyd, D. H., Vaessen, M. M., Mol, J. A., Kooistra, H. S., & Rijnberk, A. (2007). Alopecia in pomeranians and miniature poodles in association with high urinary corticoid:creatinine ratios and resistance to glucocorticoid feedback. The Veterinary Record, 160(12), 393-397. http://doi.org/10.1136/vr.160.12.393. PMid:17384290.

Chen, C. C., & Chuong, C. M. (2012). Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia. Journal of Dermatological Science, 66(1), 3-11. http://doi.org/10.1016/j.jdermsci.2012.02.007. PMid:22391240.

Frank, L. A. (2005). Growth hormone-responsive alopecia in dogs. Journal of the American Veterinary Medical Association, 226(9), 1494-1497. http://doi.org/10.2460/javma.2005.226.1494. PMid:15881999.

Frank, L. A. (2006). Comparative dermatology--canine endocrine dermatoses. Clinics in Dermatology, 24(4), 317-325. http://doi.org/10.1016/j.clindermatol.2006.04.007. PMid:16828413.

Frank, L. A., Hnilica, K. A., & Oliver, J. W. (2004). Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane. Veterinary Dermatology, 15(5), 278-284. http://doi.org/10.1111/j.1365-3164.2004.00372.x. PMid:15500479.

Frank, L. A., Hnilica, K. A., Rohrbach, B. W., & Oliver, J. W. (2003). Retrospective evaluation of sex hormones and steroid hormone intermediates in dogs with alopecia. Veterinary Dermatology, 14(2), 91-97. http://doi.org/10.1046/j.1365-3164.2003.00330.x. PMid:12662266.

Gontier, A., Youala, M., Fontaine, C., Raibon, E., Fournel, S., Briantais, P., & Rigaut, D. (2022). Efficacy and safety of 4.7 mg deslorelin acetate implants in suppressing oestrus cycle in prepubertal female dogs. Animals (Basel), 12(24), 3504. http://doi.org/10.3390/ani12243504. PMid:36552424.

Huang, H.-P., Lien, Y.-H., & Chang, P.-H. (2009). Effect of castration on hair re-growth in Pomeranians with hair cycle arrest (alopecia X). Journal of Veterinary Clinical Sciences, 2, 17-19.

Kang, Y. H., Kim, M. S., Kang, S. Y., Hyun, J. E., & Hwang, C. Y. (2024). Optimal microneedle length for hair regrowth in hair cycle arrest (alopecia X) in six dogs. Veterinary Dermatology, 35(2), 184-193. http://doi.org/10.1111/vde.13219. PMid:38057943.

Layne, E. A., & Richmond, R. V. (2018). Deslorelin implant treatment for hair cycle arrest (Alopecia X) in two intact male Keeshonden. Journal of the American Animal Hospital Association, 54(4), 231-234. http://doi.org/10.5326/ JAAHA-MS-6646. PMid:29757666.

Lucas, X. (2014). Clinical use of deslorelin (GnRH agonist) in companion animals: A review. Reproduction in Domestic Animals, 49(Suppl 4), 64-71. http://doi.org/10.1111/rda.12388. PMid:25277434.

Mausberg, E. M., Drogemuller, C., Rufenacht, S., Welle, M., Roosje, P., Suter, M., & Leeb, T. (2007). Inherited alopecia X in Pomeranians. DTW. Deutsche Tierarztliche Wochenschrift, 114(4), 129-134. PMid:17484499.

Müntener, T., Schuepbach-Regula, G., Frank, L., Rufenacht, S., & Welle, M. M. (2012). Canine noninflammatory alopecia: A comprehensive evaluation of common and distinguishing histological characteristics. Veterinary Dermatology, 23(3), 206-e44. http://doi.org/10.1111/j.1365-3164.2012.01049.x. PMid:22575019.

Stoll, S., Dietlin, C., & Nett-Mettler, C. S. (2015). Microneedling as a successful treatment for alopecia X in two Pomeranian siblings. Veterinary Dermatology, 26(5), 387-e88. http://doi.org/10.1111/vde.12236.

van Hensbergen, I., van den Broek, J., van Amersfort, K., & van der Lee, A. (2025). Evaluation of phenotypic risk indicators for the development of alopecia X (hair cycle arrest) in Pomeranian dogs in the Netherlands and Belgium. Veterinary Dermatology, 36(2), 196-204. http://doi.org/10.1111/vde.13326. PMid:39873118.

Welle, M. M. (2023). Canine noninflammatory alopecia: An approach to its classification and a diagnostic aid. Veterinary Pathology, 60(6), 748-769. http://doi.org/10.1177/03009858231170295. PMid:37191329.

Welle, M. M., Reichler, I. M., Barth, A., Forster, U., Sattler, U., & Arnold, S. (2006). Immunohistochemical localization and quantitative assessment of GnRH-, FSH-, and LH-receptor mRNA Expression in canine skin: A powerful tool to study the pathogenesis of side effects after spaying. Histochemistry and Cell Biology, 126(5), 527-535. http://doi.org/10.1007/s00418-006-0189-y. PMid:16715322.

Wu, H. M., Chang, H. M., & Leung, P. C. K. (2021). Gonadotropin-releasing hormone analogs: Mechanisms of action and clinical applications in female reproduction. Frontiers in Neuroendocrinology, 60, 100876. http:// doi.org/10.1016/j.yfrne.2020.100876. PMid:33045257.

Zanna, G., Abramo, F., Contiero, B., Zini, E., Albanese, F., Borio, E., Godizzi, F., Necci, F., Luciani, L., & Roccabianca, P. (2024). Dermoscopic findings and comparison of usefulness of longitudinal versus transversal sections in the histological diagnosis of alopecia X. Veterinary Dermatology, 35(2), 126-137. http://doi.org/10.1111/vde.13212. PMid:37867253.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2025 Priscila Alves Bastos Coimbra, Aline Bomfim Vieira