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Abstract
Adrenocortical carcinoma (ACC) is a rare condition in dogs. This type of tumor can be functional, hormone-producing, or nonfunctional. Bilateral adrenal tumors are uncommon, whereas unilateral adrenal tumors are more prevalent. Abdominal ultrasonography is crucial for detecting these lesions, which are characterized by heterogeneous parenchymal characteristics. Furthermore, elastography, a technique that assesses tissue stiffness, is useful for differentiating between malignant and benign lesions. This paper describes a case of ACC in a West Highland white terrier. The dog initially presented with dermatological changes and increased adrenal tissue stiffness, as detected by elastography. After additional examinations, including computed tomography, an adrenalectomy was successfully performed. Histopathological analysis confirmed the diagnosis of ACC. Post-surgical follow-ups included periodic ultrasonography to monitor the remaining adrenal gland. A nodular lesion was identified in the left adrenal gland during the follow-up, highlighting the importance of continuous monitoring. This case underscores the significance of an integrated approach, from the initial evaluation to the post-treatment follow-up for the effective management of ACC in dogs.
References
Balsa, I. M., & Culp, W. T. N. (2019). Use of minimally invasive surgery in the diagnosis and treatment of cancer in dogs and cats. Veterinary Sciences, 6(1), 1-12. http://doi.org/10.3390/vetsci6010033. PMid:30897763.
Bennaim, M., Shiel, R. E., & Mooney, C. T. (2019). Diagnosis of spontaneous hyperadrenocorticism in dogs. Part 2: Adrenal function testing and differentiating tests. Veterinary Journal (London, England), 252, 105343. http://doi.org/10.1016/j.tvjl.2019.105343. PMid:31554584.
Bugbee, A., Rucinsky, R., Cazabon, S., Kvitko-White, H., Lathan, P., Nichelason, A., & Rudolph, L. (2023). 2023 AAHA selected endocrinopathies of dogs and cats guidelines. Journal of the American Animal Hospital Association, 59(3), 113-135. http://doi.org/10.5326/JAAHA-MS-7368. PMid:37167252.
Cook, A. K., Spaulding, K. A., & Edwards, J. F. (2014). Clinical findings in dogs with incidental adrenal gland lesions determined by ultrasonography: 151 cases (2007–2010). Journal of the American Veterinary Medical Association, 244(10), 1181-1185. http://doi.org/10.2460/javma.244.10.1181. PMid:24786166.
Feliciano, M. A. R., Ramirez, R. A. U., Maronezi, M. C., Maciel, G. S., Avante, M. L., Senhorello, I. L. S., Mucédola, T., Gasser, B., Carvalho, C. F., & Vicente, W. R. R. (2018). Accuracy of four ultrasonography techniques in predicting histopathological classification of canine mammary carcinomas. Veterinary Radiology & Ultrasound, 59(4), 444-452. http://doi.org/10.1111/vru.12606. PMid:29430763.
Holdsworth, A., Bradley, K., Birch, S., Browne, W. J., & Barberet, V. (2014). Elastography of the normal canine liver, spleen and kidneys. Veterinary Radiology & Ultrasound, 55(6), 620-627. http://doi.org/10.1111/vru.12169. PMid:24842271.
Labelle, P., Kyles, A. E., Farver, T. B., & de Cock, H. E. V. (2004). Indicators of malignancy of canine adrenocortical tumors: Histopathology and proliferation index. Veterinary Pathology, 41(5), 490-497. http://doi.org/10.1354/ vp.41-5-490. PMid:15347821.
Li, Y., & Snedeker, J. G. (2011). Elastography: Modality-specific approaches, clinical applications, and research horizons. Skeletal Radiology, 40(4), 389-397. http://doi.org/10.1007/s00256-010-0918-0. PMid:20352427.
Lunn, K. F., & Boston, S. E. (2020). Tumors of the endocrine system. In D. M. Vail, D. H. Tham & J. M. Liptak (Eds.), Withrow & MacEwen’s Small Animal Clinical Oncology (6th ed., pp. 565-596). Elsevier. http://doi.org/10.1016/ B978-0-323-59496-7.00026-8.
Machida, T., Uchida, E., Matsuda, K., Hirayama, K., Yoshii, K., Takiguchi, M., & Taniyama, H. (2008). Aldosterone-, corticosterone- and cortisol-secreting adrenocortical carcinoma in a dog: Case report. The Journal of Veterinary Medical Science, 70(3), 317-320. http://doi.org/10.1292/jvms.70.317. PMid:18388437.
Massari, F., Nicoli, S., Romanelli, G., Buracco, P., & Zini, E. (2011). Adrenalectomy in dogs with adrenal gland tumors: 52 cases (2002–2008). Journal of the American Veterinary Medical Association, 239(2), 216-221. http://doi.org/10.2460/javma.239.2.216. PMid:21756177.
Mayhew, P. D., Boston, S. E., Zwingenberger, A. L., Giuffrida, M. A., Runge, J. J., Holt, D. E., Raleigh, J. S., Singh, A., Culp, W. T. N., Case, J. B., Steffey, M. A., & Balsa, I. M. (2019). Perioperative morbidity and mortality in dogs with invasive adrenal neoplasms treated by adrenalectomy and cavotomy. Veterinary Surgery, 48(5), 742- 750. http://doi.org/10.1111/vsu.13221. PMid:31034643.
Melián, C. (2017). Hyperadrenocorticism in dogs. In S. J. Ettinger, E.C. Feldman & E. Côte (Eds.), Textbook of Veterinary Internal Medicine (Vol. 8, pp. 4345). Éditions Elsevier.
Melián, C., Pérez-López, L., Saavedra, P., Ravelo-García, A. G., Santos, Y., & Jaber, J. R. (2021). Ultrasound evaluation of adrenal gland size in clinically healthy dogs and in dogs with hyperadrenocorticism. The Veterinary Record, 188(8), e80. http://doi.org/10.1002/vetr.80. PMid:33891740.
Nelson, R. W., & Gouto, C. G. (2014). Disorders of adrenal gland. In R. W. Nelson & C. G. Couto (Eds.), Small Animal Internal Medicine (pp. 824-843). Éditions Elsevier.
Renaudin, K., Smati, S., Wargny, M., al Ghuzlan, A., Aubert, S., Leteurtre, E., Patey, M., Sibony, M., Sturm, N., Tissier, F., Amar, L., Bertherat, J., Berthozat, C., Chabre, O., do Cao, C., Haissaguerre, M., Pierre, P., Briet, C., Vezzosi, D., Lifante, J. C., Pattou, F., Mirallie, E., Baudin, E., Cariou, B., Libe, R., & Drui, D. (2018). Clinicopathological description of 43 oncocytic adrenocortical tumors: Importance of Ki-67 in histoprognostic evaluation. Modern Pathology, 31(11), 1708-1716. http://doi.org/10.1038/s41379-018-0077-8. PMid:29921900.
Sanders, K., van Staalduinen, G. J., Uijens, M. C. M., Mol, J. A., Teske, E., Slob, A., Hesselink, J. W., Kooistra, H. S., & Galac, S. (2019). Molecular markers of prognosis in canine cortisol-secreting adrenocortical tumours. Veterinary and Comparative Oncology, 17(4), 545-552. http://doi.org/10.1111/vco.12521. PMid:31301217.
Słapa, R. Z., Kasperlik-Załuska, A. A., Migda, B., & Jakubowski, W. S. (2014). Shear wave elastography of adrenal masses is feasible and may help to differentiate between solid and cystic lesions – An initial report. Endokrynologia Polska, 65(2), 119-124. http://doi.org/10.5603/EP.2014.0017. PMid:24802735.
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