Pulmonary aspergillosis in a horse: a case report
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Keywords

equine, Aspergillus spp., pneumonia, itraconazole.

How to Cite

Melo, U. P., Ferreira, C., & Barreto, S. W. M. (2024). Pulmonary aspergillosis in a horse: a case report. Brazilian Journal of Veterinary Medicine, 46, e004723. https://doi.org/10.29374/2527-2179.bjvm004723

Abstract

Respiratory diseases considerably affect equine athletes, being the second most common cause of poor performance. Among these diseases, fungal pneumonia in horses, caused specifically by Aspergillus spp., is relatively rare but potentially fatal. Fungal pneumonia typically affects horses exposed to fungal elements due to environmental factors, immunosuppression, or previous debilitating illnesses. Treatment is complex, with minimal success due to late diagnosis and serious concomitant underlying diseases. The choice of medication depends on the site of infection, the fungal species involved, and financial considerations. This report describes a case of pulmonary aspergillosis diagnosed in a 10-year-old castrated Quarter Horse. Transtracheal lavage revealed fungal elements characteristic of Aspergillus fumigatus. Treatment with dexamethasone, bromhexine hydrochloride, and itraconazole led to a successful recovery. The diagnosis of equine aspergillosis is challenging because its clinical signs overlap with other respiratory diseases. Fungal infections like aspergillosis are gaining attention in the equine health scene. Early and accurate diagnosis is crucial to avoid unnecessary use of antibiotics and prevent antimicrobial resistance. Furthermore, veterinarians and horse handlers must be aware of the risks of spreading aspergillosis to humans, emphasizing preventative measures and respiratory protection.

https://doi.org/10.29374/2527-2179.bjvm004723
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References

Alves, R. C., Borges, I. L., Dutra, V., Júnior, F. G., Neto, E. G., Dantas, A. F., Riet-Correa, F., & Galiza, G. J. (2018). Systemic infection by Aspergillus flavus in a mare. Acta Scientiae Veterinariae, 46(Suppl 1), 345.

Busato, E. M., Meirelles, J. R. S., Castro, M. L., Abreu, A. C. M. R., Sousa, R. S., Brum, J. S., & Dornbusch, P. T. (2020). Aspergilose sistêmica em um cavalo - relato de caso. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 72(1), 65-70. http://dx.doi.org/10.1590/1678-4162-10600.

Cafarchia, C., Paradies, R., Figueredo, L. A., Padalino, B., Greco, M. F., Greco, G., & Otranto, D. (2012). A case of equine aspergillosis: A novel sampling procedure for diagnosis. Journal of Equine Veterinary Science, 32(10), 634-637. http://dx.doi.org/10.1016/j.jevs.2012.02.009.

Couëtil, L. L., Cardwell, J. M., Gerber, V., Lavoie, J.-P., Léguillette, R., & Richard, E. A. (2016). Inflammatory airway disease of horses-revised consensus statement. Journal of Veterinary Internal Medicine, 30(2), 503-515. http://dx.doi.org/10.1111/jvim.13824. PMid:26806374.

Dobiáš, R., Jahn, P., Tóthová, K., Dobešová, O., Višňovská, D., Patil, R., Škríba, A., Jaworská, P., Škorič, M., Podojil, L., Kantorová, M., Mrázek, J., Krejčí, E., Stevens, D. A., & Havlíček, V. (2023). Diagnosis of aspergillosis in horses. Journal of Fungi (Basel, Switzerland), 9(2), 161. http://dx.doi.org/10.3390/jof9020161. PMid:36836276.

Fernandes, W. R., Mori, E., & Sanches, A. (2000). Avaliação citológica de lavados traqueobrônquico e broncoalveolar em cavalos clinicamente sadios pelo método de coloração de Rosenfeld. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 52(6), 604-609. http://dx.doi.org/10.1590/S0102-09352000000600009.

Hattab, J., Vulcano, A., D’Arezzo, S., Verni, F., Tiscar, P. G., Lanteri, G., Gjurcevic, E., Tosi, U., & Marruchella, G. (2021). Aspergillus Section Fumigati pneumonia and oxalate nephrosis in a foal. Pathogens (Basel, Switzerland), 10(9), 1087. http://dx.doi.org/10.3390/pathogens10091087. PMid:34578120.

Higgins, J. C., & Pusterla, N. (2006). Fungal pneumonia in horses. Clinical Techniques in Equine Practice, 5(3), 218-224. http://dx.doi.org/10.1053/j.ctep.2006.03.017.

Lessa, D. A. B., Mori, E., Viana, E. B., Santos, O. J., Moreira, J. F. E., & Fernandes, W. R. (2005). Lavado broncoalveolar em eqüinos: revisão de literatura. Parte 1: Técnicas de colheita. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, 8(2), 213-217.

Lima, J. L. F., Venancio, F. R., Faccini, L. S., Brunner, C. B., Gomes, A. R., Del Pinho, T. S., & Bonel, J. (2021). Aspergilose sistêmica em potro (Equus caballus). Ciência Animal, 31(1), 146-152.

Lopes, P. R., Batista, M. A., Soares, R. P., Oliveira, J. G., & Leme, F. (2021). Autohemotherapy increases phagocytic activity of neutrophils and promotes cytokine production by lymphocytes in horses. Revista Brasileira de Medicina Veterinária, 43(1), e000821. http://dx.doi.org/10.29374/2527-2179.bjvm000821.

Medeiros, P. R., Figueiredo, L. S., Melo, U. P., Mariz, A. L. B., Brito Filho, E. L., Araújo, I. R. S., Silva Junior, A. L. C., Costa, M. H. S., Ferreira, C., Assis, D. B., Silva, C. R. M., Souza, A. L., & Souza, M. P. S. (2023). Survey on sanitary practices and knowledge about infectious diseases among equine owners in the State of Rio Grande do Norte, Brazil. Revista Brasileira de Medicina Veterinária, 45, e003323. http://dx.doi.org/10.29374/2527-2179.bjvm003323. PMid:38090190.

Melo, U. P., & Ferreira, C. (2022). Bacterial pneumonia in horses associated with Escherichia coli infection: Report of five cases. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 74(5), 862-868. http://dx.doi.org/10.1590/1678-4162-12410.

Melo, U. P., Ferreira, C., & Palhares, M. S. (2007). Obstrução recorrente das vias aéreas em muares: Relato de três casos. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 59(3), 627-633. http://dx.doi.org/10.1590/S0102-09352007000300012.

Melo, U. P., Ferreira, C., Feijó, F. M. C., & Santos, C. S. (2021). Pleuropneumonia séptica em potro. Brazilian Journal of Animal and Environmental Research, 4(3), 3818-3831. http://dx.doi.org/10.34188/bjaerv4n3-089.

Moreira, M. J. A., Thomassian, A., Alves, A. L. G., Hussni, C. A., & Nicoletti, J. L. M. (2004). Tratamento de aspergilose pulmonar com itraconazol em um equino. Brazilian Journal of Veterinary Research and Animal Science, 41(supl.), 238-238. http://dx.doi.org/10.11606/issn.2318-3659.v41isupl.p238-238.

Oliveira, T. M., Michelotto Junior, P. V., Fernandes, W. R., & Calomeno, S. S. (2022). Equine asthma in Brazil – a scoping review. Research, Social Development, 11(8), e30311830824. http://dx.doi.org/10.33448/rsd-v11i8.30824.

Rossi, H., Virtala, A.-M., Raekallio, M., Rahkonen, E., Rajamaki, M. M., & Mykkanen, A. (2018). Comparison of tracheal wash and bronchoalveolar lavage cytology in 154 horses with and without respiratory signs in a referral hospital over 2009–2015. Frontiers in Veterinary Science, 5, 61. http://dx.doi.org/10.3389/fvets.2018.00061. PMid:29632867.

Sales, M. P. U. (2009). Aspergilose: Do diagnóstico ao tratamento. Jornal Brasileiro de Pneumologia, 35(12), 1238-1244. http://dx.doi.org/10.1590/S1806-37132009001200012. PMid:20126927.

Silva, J. R., Castro, M. L., Busato, E. M., Deconto, I., Sousa, R., & Dornbusch, P. T. (2014). Aspergilose sistêmica em um cavalo: Relato de caso. Ciência Veterinária nos Tropicos, 17(3), 20-20.

Stewart, A. J., & Cuming, R. S. (2015). Update on fungal respiratory disease in horses. The Veterinary Clinics of North America. Equine Practice, 31(1), 43-62. http://dx.doi.org/10.1016/j.cveq.2014.11.005. PMid:25620382.

Trápaga, M. R., Poester, V. R., Mousquer, M. A., Souza, R. P., Rafael, L. A., Bonel, J., Melo, A. M., Reis, A. G., Faria, R. O., Stevens, D. A., Nogueira, C. E. W., & Xavier, M. O. (2023). Systemic aspergillosis associated with acute enterocolitis in foals. Journal de Mycologie Médicale, 33(4), 101433. http://dx.doi.org/10.1016/j.mycmed.2023.101433. PMid:37708695.

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Copyright (c) 2023 Ubiratan Pereira Melo, Cíntia Ferreira, Suziane Wilma Mota Barreto