Abstract
ABSTRACT. Gomes J.P.F. dos S., Ramos R.R., Frias D.F.R., Marques V.B., Kozusny-Andreani D.I. & Fernandes A.U. [Evidences of photodynamic therapy effect on foot rot disorders in dairy cows in the Municipality of Fernandópolis, São Paulo, Brazil.] Evidências do efeito da terapia fotodinâmica sobre infecções podais em vacas leiteiras no município de Fernandópolis, São Paulo, Brasil. Revista Brasileira de Medicina Veterinária, 38(3):257-264, 2016. Programa de Pós-Graduação em Engenharia Biomédica, Universidade Camilo Castelo Branco, Campus São José dos Campos, Estrada Doutor Altino Bondesan, 500, Distrito de Eugênio de Melo, São José dos Campos, SP 12247-016, Brasil. E-mail: zepaulofranco@hotmail.com Digital diseases represent a problem of great importance and high prevalence in dairy herds, causing numerous losses, mainly attributed to the premature disposal, decrease in milk production, weight loss, reduction of fertility and high treatment costs. This study was aimed to determine the action of photodynamic therapy effect in the treatment of digital diseases in dairy cattle in vivo and in vitro, also, to evaluate the effect of photodynamic action on isolated microorganisms. The methodology consisted of two experiments, the first one carried out a study of treatment efficacy of photodynamic therapy (PDT) using methylene blue as a photosensitizer agent in vivo by evaluating the Greenough score before and after treatment, and also another experiment in vitro under the effects of PDT in microorganisms isolated from lesions present in feeble animals. The results showed significant improvement in lameness after treatment of PDT in digital lesions in vivo and in microorganisms isolated in vitro. The study showed that the in vitro response is consistent with the clinical improvement observed in animals. We conclude that treatment with PDT was effective in reducing the Greenough and effective score in control of the isolated microorganisms.